Loading...
Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate
[Image: see text] Isocitrate dehydrogenase 1 (IDH1) is a key metabolic enzyme for maintaining cytosolic levels of α-ketoglutarate (AKG) and preserving the redox environment of the cytosol. Wild-type (WT) IDH1 converts isocitrate to AKG; however, mutant IDH1-R132H that is recurrent in human cancers c...
Na minha lista:
| Udgivet i: | Biochemistry |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2021
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8246651/ https://ncbi.nlm.nih.gov/pubmed/34143606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00059 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|