Loading...

Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate

[Image: see text] Isocitrate dehydrogenase 1 (IDH1) is a key metabolic enzyme for maintaining cytosolic levels of α-ketoglutarate (AKG) and preserving the redox environment of the cytosol. Wild-type (WT) IDH1 converts isocitrate to AKG; however, mutant IDH1-R132H that is recurrent in human cancers c...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Sesanto, Rae, Kuehn, Jessamine F., Barber, Diane L., White, Katharine A.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246651/
https://ncbi.nlm.nih.gov/pubmed/34143606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00059
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!