Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate

[Image: see text] Isocitrate dehydrogenase 1 (IDH1) is a key metabolic enzyme for maintaining cytosolic levels of α-ketoglutarate (AKG) and preserving the redox environment of the cytosol. Wild-type (WT) IDH1 converts isocitrate to AKG; however, mutant IDH1-R132H that is recurrent in human cancers c...

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Foilsithe in:Biochemistry
Main Authors: Sesanto, Rae, Kuehn, Jessamine F., Barber, Diane L., White, Katharine A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2021
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246651/
https://ncbi.nlm.nih.gov/pubmed/34143606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00059
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