Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

PURPOSE: Mutations in the IDH1 and IDH2 (IDH1/2) genes occur in ~20% of intrahepatic cholangiocarcinoma (ICC) and lead to accumulation of 2-hydroxyglutarate (2HG) in the tumor tissue. However, it remains unknown whether IDH1/2 mutations can lead to high levels of 2HG circulating in the blood and whe...

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Hauptverfasser: Borger, Darrell R., Goyal, Lipika, Yau, Thomas, Poon, Ronnie T., Ancukiewicz, Marek, Deshpande, Vikram, Christiani, David C., Liebman, Hannah M., Yang, Hua, Kim, Hyeryun, Yen, Katharine, Faris, Jason E., Iafrate, A. John, Kwak, Eunice L., Clark, Jeffrey W., Allen, Jill N., Blaszkowsky, Lawrence S., Murphy, Janet E., Saha, Supriya K., Hong, Theodore S., Wo, Jennifer Y., Ferrone, Cristina R., Tanabe, Kenneth K., Bardeesy, Nabeel, Straley, Kimberly S., Agresta, Sam, Schenkein, David P., Ellisen, Leif W., Ryan, David P., Zhu, Andrew X.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107454/
https://ncbi.nlm.nih.gov/pubmed/24478380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2649
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