Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad-based mutational profiling for patients diagnosed with a gastrointestinal malignancy has led to the novel discovery of mutations in the gene encoding...

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Autors principals: Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias-Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John
Format: Artigo
Idioma:Inglês
Publicat: AlphaMed Press 2012
Matèries:
Hepatobiliary
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267826/
https://ncbi.nlm.nih.gov/pubmed/22180306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0386
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