Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad-based mutational profiling for patients diagnosed with a gastrointestinal malignancy has led to the novel discovery of mutations in the gene encoding...

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Detalhes bibliográficos
Main Authors: Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias-Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Hepatobiliary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267826/
https://ncbi.nlm.nih.gov/pubmed/22180306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0386
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