Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad-based mutational profiling for patients diagnosed with a gastrointestinal malignancy has led to the novel discovery of mutations in the gene encoding...

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Hlavní autoři: Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias-Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2012
Témata:
Hepatobiliary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267826/
https://ncbi.nlm.nih.gov/pubmed/22180306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0386
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