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Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate
Somatic gain-of-function mutations in isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) or isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) are bona fide oncogenic drivers of acute myeloid leukemia and glioma because the neomorphic enzymes catalyze the synthesis of R-2-hydroxylutarate...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis Group
2018-12-01
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| Colecção: | OncoImmunology |
| Assuntos: | |
| Acesso em linha: | http://dx.doi.org/10.1080/2162402X.2018.1528815 |
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