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Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production
Mutationsin cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2 can lead to R(-)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site arginine residues IDH1 R132, IDH2 R172, and IDH2 R140 have been shown to result in the neomorphic production of 2HG....
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3271133/ https://ncbi.nlm.nih.gov/pubmed/21996744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.416 |
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