Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

Mutationsin cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2 can lead to R(-)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site arginine residues IDH1 R132, IDH2 R172, and IDH2 R140 have been shown to result in the neomorphic production of 2HG....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ward, Patrick S., Cross, Justin R., Lu, Chao, Weigert, Oliver, Abel-Wahab, Omar, Levine, Ross L., Weinstock, David M., Sharp, Kim A., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271133/
https://ncbi.nlm.nih.gov/pubmed/21996744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.416
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados