Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

Mutationsin cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2 can lead to R(-)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site arginine residues IDH1 R132, IDH2 R172, and IDH2 R140 have been shown to result in the neomorphic production of 2HG....

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Bibliografische gegevens
Hoofdauteurs: Ward, Patrick S., Cross, Justin R., Lu, Chao, Weigert, Oliver, Abel-Wahab, Omar, Levine, Ross L., Weinstock, David M., Sharp, Kim A., Thompson, Craig B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271133/
https://ncbi.nlm.nih.gov/pubmed/21996744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.416
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