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The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis

Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent lipid peroxidation and is implicated in several human pathologies, such as tissue ischemia, neurodegeneration, and cancer. Ferroptosis appears to be high cell-context dependent and the regulation of ferroptosis by...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Wang, Tian-Xiang, Liang, Jun-Yun, Zhang, Cheng, Xiong, Yue, Guan, Kun-Liang, Yuan, Hai-Xin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779886/
https://ncbi.nlm.nih.gov/pubmed/31591388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1984-4
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