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R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their normal catalytic activity and gained a novel function to produce R-2-hydroxyglutarate (R-2-HG). A recent study now shows that R-2-HG can reversibly promote leukemogenesis in vitro, suggesting a therap...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3652525/ https://ncbi.nlm.nih.gov/pubmed/23518346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.005 |
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