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Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates
Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2-HG). The current view on the mechanism of IDH mutation holds that 2-HG acts as an antagonist of α-KG to competitiv...
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| Publicado no: | Trends Cancer |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884165/ https://ncbi.nlm.nih.gov/pubmed/29458964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2017.12.005 |
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