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Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates

Isocitrate dehydrogenases (IDH1/2) are frequently mutated in multiple types of human cancer, resulting in neomorphic enzymes that convert α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2-HG). The current view on the mechanism of IDH mutation holds that 2-HG acts as an antagonist of α-KG to competitiv...

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Bibliographic Details
Published in:Trends Cancer
Main Authors: Ye, Dan, Guan, Kun-Liang, Xiong, Yue
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884165/
https://ncbi.nlm.nih.gov/pubmed/29458964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2017.12.005
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