Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH-mutant cells to alkylating agents

Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients. The benefit of this regime, known as PCV, was recently linked to IDH mutation that occurs frequently in gliom...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Wang, Pu, Wu, Jing, Shenghong, Ma, Zhang, Lei, Yao, Jun, Hoadley, Katherine A., Wilkerson, Matthew D., Perou, Charles M., Guan, Kun-Liang, Ye, Dan, Xiong, Yue
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694633/
https://ncbi.nlm.nih.gov/pubmed/26686626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.029
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