Wordt geladen...
Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH-mutant cells to alkylating agents
Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients. The benefit of this regime, known as PCV, was recently linked to IDH mutation that occurs frequently in gliom...
Bewaard in:
| Gepubliceerd in: | Cell Rep |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4694633/ https://ncbi.nlm.nih.gov/pubmed/26686626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.029 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|