Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients. The benefit of this regimen, known as PCV, was recently linked to IDH mutation that occurs frequently in glio...

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Hauptverfasser: Pu Wang, Jing Wu, Shenghong Ma, Lei Zhang, Jun Yao, Katherine A. Hoadley, Matthew D. Wilkerson, Charles M. Perou, Kun-Liang Guan, Dan Ye, Yue Xiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015-12-01
Schriftenreihe:Cell Reports
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2211124715013297
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