In vivo imaging of glutamine metabolism to the oncometabolite 2-hydroxyglutarate in IDH1/2 mutant tumors

The oncometabolite 2-hydroxyglutarate (2-HG) is a signature biomarker in various cancers where it accumulates as a result of mutations in isocitrate dehydrogenase (IDH). The metabolic source of 2-HG, in a wide variety of cancers, dictates both its generation and also potential therapeutic strategies...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Salamanca-Cardona, Lucia, Shah, Hardik, Poot, Alex J., Correa, Fabian M., Di Gialleonardo, Valentina, Lui, Hui, Miloushev, Vesselin Z., Granlund, Kristin L., Tee, Sui S., Cross, Justin R., Thompson, Craig B., Keshari, Kayvan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718944/
https://ncbi.nlm.nih.gov/pubmed/29056515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.10.001
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