The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate

Since polycystic kidney disease (PKD) was first noted over 30 years ago to have neoplastic parallels, there has been a resurgent interest in elucidating neoplasia-relevant pathways in PKD. Taking a nontargeted metabolomics approach in the B6(Cg)-Cys1(cpk/)J (cpk) mouse model of recessive PKD, we hav...

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Опубликовано в: :Am J Physiol Renal Physiol
Главные авторы: Hwang, Vicki J., Kim, Jeffrey, Rand, Amy, Yang, Chaozhe, Sturdivant, Steve, Hammock, Bruce, Bell, P. Darwin, Guay-Woodford, Lisa M., Weiss, Robert H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2015
Предметы:
Rapid Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572393/
https://ncbi.nlm.nih.gov/pubmed/26155843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00238.2015
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