Potent immunosuppressive effects of the oncometabolite R-2-hydroxyglutarate

Somatic gain-of-function mutations in isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) or isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) are bona fide oncogenic drivers of acute myeloid leukemia and glioma because the neomorphic enzymes catalyze the synthesis of R-2-hydroxylutarate...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Galluzzi, Lorenzo, Kroemer, Guido
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
Subjects:
Editorial
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279319/
https://ncbi.nlm.nih.gov/pubmed/30524910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1528815
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