The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

Many enzymes make “mistakes”. Consequently, repair enzymes have evolved to correct these mistakes. For example, lactate dehydrogenase (LDH) and mitochondrial malate dehydrogenase (mMDH) slowly catalyze the reduction of 2-oxoglutarate (2-OG) to the oncometabolite l-2-hydroxyglutarate (l-2-HG). l-2-HG...

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Pubblicato in:Biology (Basel)
Autori principali: Hariharan, Vivek A., Denton, Travis T., Paraszcszak, Sarah, McEvoy, Kyle, Jeitner, Thomas M., Krasnikov, Boris F., Cooper, Arthur J. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485471/
https://ncbi.nlm.nih.gov/pubmed/28358347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology6020024
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