The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of iso...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Carbonneau, Mélissa, M. Gagné, Laurence, Lalonde, Marie-Eve, Germain, Marie-Anne, Motorina, Alena, Guiot, Marie-Christine, Secco, Blandine, Vincent, Emma E., Tumber, Anthony, Hulea, Laura, Bergeman, Jonathan, Oppermann, Udo, Jones, Russell G., Laplante, Mathieu, Topisirovic, Ivan, Petrecca, Kevin, Huot, Marc-Étienne, Mallette, Frédérick A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027283/
https://ncbi.nlm.nih.gov/pubmed/27624942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12700
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