mTOR signaling at a glance

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2009

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2010

mTOR signaling in growth control and disease

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2012

mTOR Signaling

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2012

An emerging role of mTOR in lipid biosynthesis

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2009

Regulation of mTORC1 and its impact on gene expression at a glance

Por Laplante, Mathieu, Sabatini, David M.
Publicado em 2013

Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance

Por Chabot, François, Caron, Alexandre, Laplante, Mathieu, St-Pierre, David H
Publicado em 2014

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

Por Festuccia, William T., Pouliot, Philippe, Bakan, Inan, Sabatini, David M., Laplante, Mathieu
Publicado em 2014

Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice

Por Labbé, Sébastien M., Caron, Alexandre, Chechi, Kanta, Laplante, Mathieu, Lecomte, Roger, Richard, Denis
Publicado no Am J Physiol Endocrinol Metab (2016)

DEPTOR cell-autonomously promotes adipogenesis and its expression is associated with obesity

Por Laplante, Mathieu, Horvat, Simon, Festuccia, William T., Birsoy, Kivanc, Prevorsek, Zala, Efeyan, Alejo, Sabatini, David M.
Publicado em 2012

DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance

Por Caron, Alexandre, Labbé, Sébastien M., Mouchiroud, Mathilde, Huard, Renaud, Lanfray, Damien, Richard, Denis, Laplante, Mathieu
Publicado no Am J Physiol Regul Integr Comp Physiol (2016)

Depot-specific effects of the PPARγ agonist rosiglitazone on adipose tissue glucose uptake and metabolism

Por Festuccia, William T., Blanchard, Pierre-Gilles, Turcotte, Véronique, Laplante, Mathieu, Sariahmetoglu, Meltem, Brindley, David N., Deshaies, Yves
Publicado em 2009

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

Por Lanfray, Damien, Caron, Alexandre, Roy, Marie-Claude, Laplante, Mathieu, Morin, Fabrice, Leprince, Jérôme, Tonon, Marie-Christine, Richard, Denis
Publicado no eLife (2016)

DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival

Por Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.
Publicado em 2009

A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver

Por Sood, Aditi, Jeyaraju, Danny Vijey, Prudent, Julien, Caron, Alexandre, Lemieux, Philippe, McBride, Heidi May, Laplante, Mathieu, Tóth, Katalin, Pellegrini, Luca
Publicado no Proc Natl Acad Sci U S A (2014)

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

Por Caron, Alexandre, Labbé, Sébastien M., Lanfray, Damien, Blanchard, Pierre-Gilles, Villot, Romain, Roy, Christian, Sabatini, David M., Richard, Denis, Laplante, Mathieu
Publicado no Mol Metab (2015)

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold

Por Labbé, Sébastien M., Mouchiroud, Mathilde, Caron, Alexandre, Secco, Blandine, Freinkman, Elizaveta, Lamoureux, Guillaume, Gélinas, Yves, Lecomte, Roger, Bossé, Yohan, Chimin, Patricia, Festuccia, William T., Richard, Denis, Laplante, Mathieu
Publicado no Sci Rep (2016)

Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism

Por Dallaire, Patrice, Bellmann, Kerstin, Laplante, Mathieu, Gélinas, Stéphanie, Centeno-Baez, Carolina, Penfornis, Patrice, Peyot, Marie-Line, Latour, Martin G., Lamontagne, Julien, Trujillo, Maria E., Scherer, Philipp E., Prentki, Marc, Deshaies, Yves, Marette, André
Publicado em 2008

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma

Por Gendron, David R., Lecours, Pascale B., Lemay, Anne-Marie, Beaulieu, Marie-Josée, Huppé, Carole-Ann, Lee-Gosselin, Audrey, Flamand, Nicolas, Don, Anthony S., Bissonnette, Élyse, Blanchet, Marie-Renée, Laplante, Mathieu, Bourgoin, Sylvain G., Bossé, Ynuk, Marsolais, David
Publicado no Front Pharmacol (2017)

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Por Carbonneau, Mélissa, M. Gagné, Laurence, Lalonde, Marie-Eve, Germain, Marie-Anne, Motorina, Alena, Guiot, Marie-Christine, Secco, Blandine, Vincent, Emma E., Tumber, Anthony, Hulea, Laura, Bergeman, Jonathan, Oppermann, Udo, Jones, Russell G., Laplante, Mathieu, Topisirovic, Ivan, Petrecca, Kevin, Huot, Marc-Étienne, Mallette, Frédérick A.
Publicado no Nat Commun (2016)