A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma

In asthma, excessive bronchial narrowing associated with thickening of the airway smooth muscle (ASM) causes respiratory distress. Numerous pharmacological agents prevent experimental airway hyperresponsiveness (AHR) when delivered prophylactically. However, most fail to resolve this feature after d...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Gendron, David R., Lecours, Pascale B., Lemay, Anne-Marie, Beaulieu, Marie-Josée, Huppé, Carole-Ann, Lee-Gosselin, Audrey, Flamand, Nicolas, Don, Anthony S., Bissonnette, Élyse, Blanchet, Marie-Renée, Laplante, Mathieu, Bourgoin, Sylvain G., Bossé, Ynuk, Marsolais, David
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318459/
https://ncbi.nlm.nih.gov/pubmed/28270767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00078
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