A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma

In asthma, excessive bronchial narrowing associated with thickening of the airway smooth muscle (ASM) causes respiratory distress. Numerous pharmacological agents prevent experimental airway hyperresponsiveness (AHR) when delivered prophylactically. However, most fail to resolve this feature after d...

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Vydáno v:Front Pharmacol
Hlavní autoři: Gendron, David R., Lecours, Pascale B., Lemay, Anne-Marie, Beaulieu, Marie-Josée, Huppé, Carole-Ann, Lee-Gosselin, Audrey, Flamand, Nicolas, Don, Anthony S., Bissonnette, Élyse, Blanchet, Marie-Renée, Laplante, Mathieu, Bourgoin, Sylvain G., Bossé, Ynuk, Marsolais, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318459/
https://ncbi.nlm.nih.gov/pubmed/28270767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00078
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