Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

BACKGROUND/OBJECTIVE: The mechanistic target of rapamycin (mTOR) is a serine–threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulate energy homeostasis. DEP-domain containing mTOR-interacting protein (DEPTOR) is part of these complexes and is known to dampen...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Caron, Alexandre, Labbé, Sébastien M., Lanfray, Damien, Blanchard, Pierre-Gilles, Villot, Romain, Roy, Christian, Sabatini, David M., Richard, Denis, Laplante, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735664/
https://ncbi.nlm.nih.gov/pubmed/26909318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.11.005
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