Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism

OBJECTIVE—Synthetic ligands for peroxisome proliferator–activated receptor-γ (PPAR-γ) improve insulin sensitivity in obesity, but it is still unclear whether inflammatory signals modulate their metabolic actions. In this study, we tested whether targeted disruption of inducible nitric oxide (NO) syn...

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Detalhes bibliográficos
Main Authors: Dallaire, Patrice, Bellmann, Kerstin, Laplante, Mathieu, Gélinas, Stéphanie, Centeno-Baez, Carolina, Penfornis, Patrice, Peyot, Marie-Line, Latour, Martin G., Lamontagne, Julien, Trujillo, Maria E., Scherer, Philipp E., Prentki, Marc, Deshaies, Yves, Marette, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494686/
https://ncbi.nlm.nih.gov/pubmed/18458147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0540
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