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A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver

Hepatic metabolism requires mitochondria to adapt their bioenergetic and biosynthetic output to accompany the ever-changing anabolic/catabolic state of the liver cell, but the wiring of this process is still largely unknown. Using a postprandial mouse liver model and quantitative cryo-EM analysis, w...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sood, Aditi, Jeyaraju, Danny Vijey, Prudent, Julien, Caron, Alexandre, Lemieux, Philippe, McBride, Heidi May, Laplante, Mathieu, Tóth, Katalin, Pellegrini, Luca
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234614/
https://ncbi.nlm.nih.gov/pubmed/25352671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408061111
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