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Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion
Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria. OPA1 is mutated in dominant optic atrophy, a neurodegenerative disease of the optic nerve. In yeast...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
The American Society for Cell Biology
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719570/ https://ncbi.nlm.nih.gov/pubmed/19477917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-03-0252 |
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