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Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria. OPA1 is mutated in dominant optic atrophy, a neurodegenerative disease of the optic nerve. In yeast...

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Bibliographische Detailangaben
Hauptverfasser: Song, Zhiyin, Ghochani, Mariam, McCaffery, J. Michael, Frey, Terrence G., Chan, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719570/
https://ncbi.nlm.nih.gov/pubmed/19477917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-03-0252
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