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DEPTOR cell-autonomously promotes adipogenesis and its expression is associated with obesity

DEP domain containing mTOR-interacting protein (DEPTOR) inhibits the mechanistic target of rapamycin (mTOR) but its in vivo functions are unknown. Previous work indicates that Deptor is part of the Fob3a quantitative trait locus (QTL) linked to obesity/leanness in mice with Deptor expression being e...

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Detalhes bibliográficos
Main Authors: Laplante, Mathieu, Horvat, Simon, Festuccia, William T., Birsoy, Kivanc, Prevorsek, Zala, Efeyan, Alejo, Sabatini, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463374/
https://ncbi.nlm.nih.gov/pubmed/22883231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.07.008
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