Effects of interface mutations on association modes and electron-transfer rates between proteins

af Kang, Seong A., Crane, Brian R.
Udgivet 2005

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

af Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Sabatini, David M., Kang, Seong A.
Udgivet 2010

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

af Mahoney, Sarah J., Narayan, Sridhar, Molz, Lisa, Berstler, Lauren A., Kang, Seong A., Vlasuk, George P., Saiah, Eddine
Udgivet i Nat Commun (2018)

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatm...

af Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Sabatini, David M., Gray, Nathanael S.
Udgivet 2011

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes

af Fonslow, Bryan R., Kang, Seong A., Gestaut, Daniel R., Graczyk, Beth, Davis, Trisha N., Sabatini, David M., Yates, John R.
Udgivet 2010

DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival

af Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.
Udgivet 2009

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

af Thoreen, Carson C., Kang, Seong A., Chang, Jae Won, Liu, Qingsong, Zhang, Jianming, Gao, Yi, Reichling, Laurie J., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Udgivet 2009

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

af Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Choi, Hwan Geun, Waller, David L., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Udgivet 2011

Correction: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

af Thoreen, Carson C., Kang, Seong A., Chang, Jae Won, Liu, Qingsong, Zhang, Jianming, Gao, Yi, Reichling, Laurie J., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Udgivet i J Biol Chem (2020)

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective Mammalian Target of Rapa...

af Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Udgivet 2010

Development of ATP-competitive mTOR Inhibitors

af Liu, Qingsong, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Wang, Jinhua, Chang, Jae Won, Markhard, Andrew, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Udgivet 2012

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

af Kang, Seong A., Pacold, Michael E., Cervantes, Christopher L., Lim, Daniel, Lou, Hua Jane, Ottina, Kathleen, Gray, Nathanael S., Turk, Benjamin E., Yaffe, Michael B., Sabatini, David M.
Udgivet 2013

ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP

af Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Thoreen, Carson C., Kang, Seong A., Sabatini, David M., Mills, Gordon B., Brugge, Joan S.
Udgivet i Cancer Res (2016)

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling

af Hsu, Peggy P., Kang, Seong A., Rameseder, Jonathan, Zhang, Yi, Ottina, Kathleen A., Lim, Daniel, Peterson, Timothy R., Choi, Yongmun, Gray, Nathanael S., Yaffe, Michael B., Marto, Jarrod A., Sabatini, David M.
Udgivet 2011

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

af Peterson, Timothy R., Sengupta, Shomit S., Harris, Thurl E., Carmack, Anne E., Kang, Seong A., Balderas, Eric, Guertin, David A., Madden, Katherine L., Carpenter, Anne E., Finck, Brian N., Sabatini, David M.
Udgivet 2011

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

af Liu, Qingsong, Kirubakaran, Sivapriya, Hur, Wooyoung, Niepel, Mario, Westover, Kenneth, Thoreen, Carson C., Wang, Jinhua, Ni, Jing, Patricelli, Matthew P., Vogel, Kurt, Riddle, Steve, Waller, David L., Traynor, Ryan, Sanda, Takaomi, Zhao, Zheng, Kang, Seong A., Zhao, Jean, Look, A. Thomas, Sorger, Peter K., Sabatini, David M., Gray, Nathanael S.
Udgivet 2012

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR

af Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Liu, Yan, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Sabatini, David M., Gray, Nathanael S.
Udgivet 2013