Cell–cell and cell–matrix interactions

Por Muranen, Taru
Publicado em 2013

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity

Por Laulajainen, Minja, Melikova, Maria, Muranen, Taru, Carpén, Olli, Grönholm, Mikaela
Publicado em 2012

Multistep Phosphorylation by Oncogenic Kinases Enhances the Degradation of the NF2 Tumor Suppressor Merlin

Por Laulajainen, Minja, Muranen, Taru, Nyman, Tuula A, Carpén, Olli, Grönholm, Mikaela
Publicado em 2011

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications

Por Muranen, Taru A, Greco, Dario, Fagerholm, Rainer, Kilpivaara, Outi, Kämpjärvi, Kati, Aittomäki, Kristiina, Blomqvist, Carl, Heikkilä, Päivi, Borg, Åke, Nevanlinna, Heli
Publicado em 2011

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium

Por Iwanicki, Marcin P., Davidowitz, Rachel A., Ng, Mei Rosa, Besser, Achim, Muranen, Taru, Merritt, Melissa, Danuser, Gaudenz, Ince, Tan, Brugge, Joan S.
Publicado em 2011

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

Por Muranen, Taru, Selfors, Laura M., Worster, Devin T., Iwanicki, Marcin P., Song, Loling, Morales, Fabiana C., Gao, Sizhen, Mills, Gordon B., Brugge, Joan S.
Publicado em 2012

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition

Por Iwanicki, Marcin P., Chen, Hsing-Yu, Iavarone, Claudia, Zervantonakis, Ioannis K., Muranen, Taru, Novak, Marián, Ince, Tan A., Drapkin, Ronny, Brugge, Joan S.
Publicado no JCI Insight (2016)

Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families

Por Muranen, Taru A., Mavaddat, Nasim, Khan, Sofia, Fagerholm, Rainer, Pelttari, Liisa, Lee, Andrew, Aittomäki, Kristiina, Blomqvist, Carl, Easton, Douglas F., Nevanlinna, Heli
Publicado no Breast Cancer Res Treat (2016)

ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP

Por Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Thoreen, Carson C., Kang, Seong A., Sabatini, David M., Mills, Gordon B., Brugge, Joan S.
Publicado no Cancer Res (2016)

Starved epithelial cells uptake extracellular matrix for survival

Por Muranen, Taru, Iwanicki, Marcin P., Curry, Natasha L., Hwang, Julie, DuBois, Cory D., Coloff, Jonathan L., Hitchcock, Daniel S., Clish, Clary B., Brugge, Joan S., Kalaany, Nada Y.
Publicado no Nat Commun (2017)

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer

Por Elkabets, Moshe, Vora, Sadhna, Juric, Dejan, Morse, Natasha, Mino-Kenudson, Mari, Muranen, Taru, Tao, Jessica, Campos, Ana Bosch, Rodon, Jordi, Ibrahim, Yasir H., Serra, Violeta, Rodrik-Outmezguine, Vanessa, Hazra, Saswati, Singh, Sharat, Kim, Phillip, Quadt, Cornelia, Liu, Manway, Huang, Alan, Rosen, Neal, Engelman, Jeffrey A., Scaltriti, Maurizio, Baselga, José
Publicado em 2013

Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer development

Por Liu, Jianjun, Desai, Kartiki Vasant, Li, Yuqing, Banu, Shakeela, Lee, Yew Kok, Qu, Dianbo, Heikkinen, Tuomas, Aaltonen, Kirsimari, Muranen, Taru A., Kajiji, Tasneem Shabbir, Bonnard, Carine, Aittomäki, Kristiina, von Smitten, Karl, Blomqvist, Carl, Hopper, John L., Southey, Melissa C., Brauch, Hiltrud, Chenevix-Trench, Georgia, Beesley, Jonathan, Spurdle, Amanda B., Chen, Xiaoqing, Czene, Kamila, Hall, Per, Nevanlinna, Heli, Liu, Edison T.
Publicado em 2010

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Por Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine R., Bass, Adam J., Heffron, Gregory, Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew, Richardson, Andrea L, Chin, Lynda, Wagner, Gerhard, Asara, John M, Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.
Publicado em 2011

Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association Consortium

Por Muranen, Taru A., Blomqvist, Carl, Dörk, Thilo, Jakubowska, Anna, Heikkilä, Päivi, Fagerholm, Rainer, Greco, Dario, Aittomäki, Kristiina, Bojesen, Stig E., Shah, Mitul, Dunning, Alison M., Rhenius, Valerie, Hall, Per, Czene, Kamila, Brand, Judith S., Darabi, Hatef, Chang-Claude, Jenny, Rudolph, Anja, Nordestgaard, Børge G., Couch, Fergus J., Hart, Steven N., Figueroa, Jonine, García-Closas, Montserrat, Fasching, Peter A., Beckmann, Matthias W., Li, Jingmei, Liu, Jianjun, Andrulis, Irene L., Winqvist, Robert, Pylkäs, Katri, Mannermaa, Arto, Kataja, Vesa, Lindblom, Annika, Margolin, Sara, Lubinski, Jan, Dubrowinskaja, Natalia, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Easton, Douglas F., Pharoah, Paul D. P., Schmidt, Marjanka K., Nevanlinna, Heli
Publicado no Breast Cancer Res (2016)

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

Por Fagerholm, Rainer, Schmidt, Marjanka K., Khan, Sofia, Rafiq, Sajjad, Tapper, William, Aittomäki, Kristiina, Greco, Dario, Heikkinen, Tuomas, Muranen, Taru A., Fasching, Peter A., Janni, Wolfgang, Weinshilboum, Richard, Loehberg, Christian R., Hopper, John L., Southey, Melissa C., Keeman, Renske, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Chenevix-Trench, Georgia, Investigators, kConFab, Lambrechts, Diether, Wildiers, Hans, Chang-Claude, Jenny, Seibold, Petra, Couch, Fergus J., Olson, Janet E., Andrulis, Irene L., Knight, Julia A., García-Closas, Montserrat, Figueroa, Jonine, Hooning, Maartje J., Jager, Agnes, Shah, Mitul, Perkins, Barbara J., Luben, Robert, Hamann, Ute, Kabisch, Maria, Czene, Kamila, Hall, Per, Easton, Douglas F., Pharoah, Paul D.P., Liu, Jianjun, Eccles, Diana, Blomqvist, Carl, Nevanlinna, Heli
Publicado no Oncotarget (2015)

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Por Ali, Alaa M.G., Schmidt, Marjanka K., Bolla, Manjeet K., Wang, Qin, Gago-Dominguez, M., Castelao, J. Esteban, Carracedo, Angel, Garzón, Victor Muñoz, Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Chang-Claude, Jenny, Vrieling, Alina, Rudolph, Anja, Seibold, Petra, Nevanlinna, Heli, Muranen, Taru A., Aaltonen, Kirsimari, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, John, Esther M., Sherman, Mark, Lissowska, Jolanta, Figueroa, Jonine, Garcia-Closas, Montserrat, Anton-Culver, Hoda, Shah, Mitul, Hopper, John L., Trichopoulou, Antonia, Bueno-de-Mesquita, Bas, Krogh, Vittorio, Weiderpass, Elisabete, Andersson, Anne, Clavel-Chapelon, Françoise, Dossus, Laure, Fagherazzi, Guy, Peeters, Petra H., Olsen, Anja, Wishart, Gordon C., Easton, Douglas F., Borgquist, Signe, Overvad, Kim, Barricarte, Aurelio, González, Carlos A., Sánchez, María-José, Amiano, Pilar, Riboli, Elio, Key, Tim, Pharoah, Paul D.
Publicado no Cancer Epidemiol Biomarkers Prev (2014)

CHEK2*1100delC Heterozygosity in Women With Breast Cancer Associated With Early Death, Breast Cancer–Specific Death, and Increased Risk of a Second Breast Cancer

Por Weischer, Maren, Nordestgaard, Børge G., Pharoah, Paul, Bolla, Manjeet K., Nevanlinna, Heli, van't Veer, Laura J., Garcia-Closas, Montserrat, Hopper, John L., Hall, Per, Andrulis, Irene L., Devilee, Peter, Fasching, Peter A., Anton-Culver, Hoda, Lambrechts, Diether, Hooning, Maartje, Cox, Angela, Giles, Graham G., Burwinkel, Barbara, Lindblom, Annika, Couch, Fergus J., Mannermaa, Arto, Grenaker Alnæs, Grethe, John, Esther M., Dörk, Thilo, Flyger, Henrik, Dunning, Alison M., Wang, Qin, Muranen, Taru A., van Hien, Richard, Figueroa, Jonine, Southey, Melissa C., Czene, Kamila, Knight, Julia A., Tollenaar, Rob A.E.M., Beckmann, Matthias W., Ziogas, Argyrios, Christiaens, Marie-Rose, Collée, Johanna Margriet, Reed, Malcolm W.R., Severi, Gianluca, Marme, Frederik, Margolin, Sara, Olson, Janet E., Kosma, Veli-Matti, Kristensen, Vessela N., Miron, Alexander, Bogdanova, Natalia, Shah, Mitul, Blomqvist, Carl, Broeks, Annegien, Sherman, Mark, Phillips, Kelly-Anne, Li, Jingmei, Liu, Jianjun, Glendon, Gord, Seynaeve, Caroline, Ekici, Arif B., Leunen, Karin, Kriege, Mieke, Cross, Simon S., Baglietto, Laura, Sohn, Christof, Wang, Xianshu, Kataja, Vesa, Børresen-Dale, Anne-Lise, Meyer, Andreas, Easton, Douglas F., Schmidt, Marjanka K., Bojesen, Stig E.
Publicado em 2012

Genetic modifiers of CHEK2*1100delC associated breast cancer risk

Por Muranen, Taru A., Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul D.P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Bojesen, Stig E., Nordestgaard, Børge G., Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V., Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Peto, Julian, dos Santos Silva, Isabel, Couch, Fergus J., Olson, Janet E., Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Cross, Simon S., Sawyer, Elinor J., Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John W.M., Fasching, Peter A., Beckmann, Matthias W., Andrulis, Irene L., Knight, Julia A., Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G., Milne, Roger L., Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L., Southey, Melissa C., John, Esther M., Whittemore, Alice S., Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F., Schmidt, Marjanka K., Nevanlinna, Heli
Publicado no Genet Med (2016)

Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

Por Schmidt, Marjanka K., Hogervorst, Frans, van Hien, Richard, Cornelissen, Sten, Broeks, Annegien, Adank, Muriel A., Meijers, Hanne, Waisfisz, Quinten, Hollestelle, Antoinette, Schutte, Mieke, van den Ouweland, Ans, Hooning, Maartje, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Antoniou, Antonis C., Arndt, Volker, Bermisheva, Marina, Bogdanova, Natalia V., Bolla, Manjeet K., Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Dunning, Alison M., Fasching, Peter A., Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Galle, Eva, García-Closas, Montserrat, Giles, Graham G., Haeberle, Lothar, Hall, Per, Hillemanns, Peter, Hopper, John L., Jakubowska, Anna, John, Esther M., Jones, Michael, Khusnutdinova, Elza, Knight, Julia A., Kosma, Veli-Matti, Kristensen, Vessela, Lee, Andrew, Lindblom, Annika, Lubinski, Jan, Mannermaa, Arto, Margolin, Sara, Meindl, Alfons, Milne, Roger L., Muranen, Taru A., Newcomb, Polly A., Offit, Kenneth, Park-Simon, Tjoung-Won, Peto, Julian, Pharoah, Paul D.P., Robson, Mark, Rudolph, Anja, Sawyer, Elinor J., Schmutzler, Rita K., Seynaeve, Caroline, Soens, Julie, Southey, Melissa C., Spurdle, Amanda B., Surowy, Harald, Swerdlow, Anthony, Tollenaar, Rob A.E.M., Tomlinson, Ian, Trentham-Dietz, Amy, Vachon, Celine, Wang, Qin, Whittemore, Alice S., Ziogas, Argyrios, van der Kolk, Lizet, Nevanlinna, Heli, Dörk, Thilo, Bojesen, Stig, Easton, Douglas F.
Publicado no J Clin Oncol (2016)

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

Por Lei, Jieping, Rudolph, Anja, Moysich, Kirsten B, Rafiq, Sajjad, Behrens, Sabine, Goode, Ellen L, Pharoah, Paul PD, Seibold, Petra, Fasching, Peter A, Andrulis, Irene L, Kristensen, Vessela N, Couch, Fergus J, Hamann, Ute, Hooning, Maartje J, Nevanlinna, Heli, Eilber, Ursula, Bolla, Manjeet K, Dennis, Joe, Wang, Qin, Lindblom, Annika, Mannermaa, Arto, Lambrechts, Diether, García-Closas, Montserrat, Hall, Per, Chenevix-Trench, Georgia, Shah, Mitul, Luben, Robert, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Knight, Julia A, Glendon, Gord, Tchatchou, Sandrine, Alnæs, Grethe I Grenaker, Borresen-Dale, Anne-Lise, Nord, Silje, Olson, Janet E, Hallberg, Emily, Vachon, Celine, Torres, Diana, Ulmer, Hans-Ulrich, Rüdiger, Thomas, Jager, Agnes, van Deurzen, Carolien HM, Tilanus-Linthorst, Madeleine MA, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Kosma, Veli-Matti, Hartikainen, Jaana M, Kataja, Vesa, Hatse, Sigrid, Wildiers, Hans, Smeets, Ann, Figueroa, Jonine, Chanock, Stephen J, Lissowska, Jolanta, Li, Jingmei, Humphreys, Keith, Phillips, Kelly-Anne, Linn, Sabine, Cornelissen, Sten, van den Broek, Sandra Alexandra J, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K, Yoo, Keun-Young, Hsiung, Chia-Ni, Wu, Pei-Ei, Hou, Ming-Feng, Shen, Chen-Yang, Teo, Soo Hwang, Taib, Nur Aishah Mohd, Yip, Cheng Har, Ho, Gwo Fuang, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tajima, Kazuo, Dunning, Alison M, Benitez, Javier, Czene, Kamila, Sucheston, Lara E, Maishman, Tom, Tapper, William J, Eccles, Diana, Easton, Douglas F, Schmidt, Marjanka K, Chang-Claude, Jenny
Publicado no Breast Cancer Res (2015)