Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants

Por Karinen, Sirkku, Heikkinen, Tuomas, Nevanlinna, Heli, Hautaniemi, Sampsa
Publicado em 2011

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12

Por Mäkinen, Netta, Aavikko, Mervi, Heikkinen, Tuomas, Taipale, Minna, Taipale, Jussi, Koivisto-Korander, Riitta, Bützow, Ralf, Vahteristo, Pia
Publicado no PLoS Genet (2016)

Variants on the promoter region of PTEN affect breast cancer progression and patient survival

Por Heikkinen, Tuomas, Greco, Dario, Pelttari, Liisa M, Tommiska, Johanna, Vahteristo, Pia, Heikkilä, Päivi, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli
Publicado em 2011

Identification of genetic markers with synergistic survival effect in cancer

Por Louhimo, Riku, Laakso, Marko, Heikkinen, Tuomas, Laitinen, Susanna, Manninen, Pekka, Rogojin, Vladimir, Miettinen, Minna, Blomqvist, Carl, Liu, Jianjun, Nevanlinna, Heli, Hautaniemi, Sampsa
Publicado em 2013

MiR-34a Expression Has an Effect for Lower Risk of Metastasis and Associates with Expression Patterns Predicting Clinical Outcome in Breast Cancer

Por Peurala, Hanna, Greco, Dario, Heikkinen, Tuomas, Kaur, Sippy, Bartkova, Jirina, Jamshidi, Maral, Aittomäki, Kristiina, Heikkilä, Päivi, Bartek, Jiri, Blomqvist, Carl, Bützow, Ralf, Nevanlinna, Heli
Publicado em 2011

MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas

Por Kämpjärvi, Kati, Mäkinen, Netta, Mehine, Miika, Välipakka, Salla, Uimari, Outi, Pitkänen, Esa, Heinonen, Hanna-Riikka, Heikkinen, Tuomas, Tolvanen, Jaana, Ahtikoski, Anne, Frizzell, Norma, Sarvilinna, Nanna, Sjöberg, Jari, Bützow, Ralf, Aaltonen, Lauri A, Vahteristo, Pia
Publicado no Br J Cancer (2016)

Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

Por Low, Yen Ling, Li, Yuqing, Humphreys, Keith, Thalamuthu, Anbupalam, Li, Yi, Darabi, Hatef, Wedrén, Sara, Bonnard, Carine, Czene, Kamila, Iles, Mark M., Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Hall, Per, Liu, Edison T., Liu, Jianjun
Publicado em 2010

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

Por Kämpjärvi, Kati, Järvinen, Tiina M., Heikkinen, Tuomas, Ruppert, Amy S., Senter, Leigha, Hoag, Kevin W., Dufva, Olli, Kontro, Mika, Rassenti, Laura, Hertlein, Erin, Kipps, Thomas J., Porkka, Kimmo, Byrd, John C., de la Chapelle, Albert, Vahteristo, Pia
Publicado no Oncotarget (2014)

Genetic variation of ESR1 and its co-activator PPARGC1B is synergistic in augmenting the risk of estrogen receptor-positive breast cancer

Por Li, Yuqing, Li, Yi, Wedrén, Sara, Li, Guoliang, Charn, Tze Howe, Desai, Kartiki Vasant, Bonnard, Carine, Czene, Kamila, Humphreys, Keith, Darabi, Hatef, Einarsdóttir, Kristjana, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Chia, Kee Seng, Nevanlinna, Heli, Hall, Per, Liu, Edison T, Liu, Jianjun
Publicado em 2011

Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families

Por Arason, Adalgeir, Gunnarsson, Haukur, Johannesdottir, Gudrun, Jonasson, Kristjan, Bendahl, Pär-Ola, Gillanders, Elizabeth M, Agnarsson, Bjarni A, Jönsson, Göran, Pylkäs, Katri, Mustonen, Aki, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Melin, Beatrice, Johannsson, Oskar TH, Møller, Pål, Winqvist, Robert, Nevanlinna, Heli, Borg, Åke, Barkardottir, Rosa B
Publicado em 2010

Germ line variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome

Por Jamshidi, Maral, Schmidt, Marjanka K, Dörk, Thilo, Garcia-Closas, Montserrat, Heikkinen, Tuomas, Cornelissen, Sten, van den Broek, Alexandra J, Schürmann, Peter, Meyer, Andreas, Park-Simon, Tjoung-Won, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Keong, Garrett Teoh Hor, Irwanto, Astrid, Laakso, Marko, Hautaniemi, Sampsa, Aittomäki, Kristiina, Blomqvist, Carl, Liu, Jianjun, Nevalinna, Heli
Publicado em 2012

Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer development

Por Liu, Jianjun, Desai, Kartiki Vasant, Li, Yuqing, Banu, Shakeela, Lee, Yew Kok, Qu, Dianbo, Heikkinen, Tuomas, Aaltonen, Kirsimari, Muranen, Taru A., Kajiji, Tasneem Shabbir, Bonnard, Carine, Aittomäki, Kristiina, von Smitten, Karl, Blomqvist, Carl, Hopper, John L., Southey, Melissa C., Brauch, Hiltrud, Chenevix-Trench, Georgia, Beesley, Jonathan, Spurdle, Amanda B., Chen, Xiaoqing, Czene, Kamila, Hall, Per, Nevanlinna, Heli, Liu, Edison T.
Publicado em 2010

A genome-wide association scan on estrogen receptor-negative breast cancer

Por Li, Jingmei, Humphreys, Keith, Darabi, Hatef, Rosin, Gustaf, Hannelius, Ulf, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Pharoah, Paul DP, Dunning, Alison M, Ahmed, Shahana, Hooning, Maartje J, Hollestelle, Antoinette, Oldenburg, Rogier A, Alfredsson, Lars, Palotie, Aarno, Peltonen-Palotie, Leena, Irwanto, Astrid, Low, Hui Qi, Teoh, Garrett HK, Thalamuthu, Anbupalam, Kere, Juha, D'Amato, Mauro, Easton, Douglas F, Nevanlinna, Heli, Liu, Jianjun, Czene, Kamila, Hall, Per
Publicado em 2010

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases...

Por Blows, Fiona M., Driver, Kristy E., Schmidt, Marjanka K., Broeks, Annegien, van Leeuwen, Flora E., Wesseling, Jelle, Cheang, Maggie C., Gelmon, Karen, Nielsen, Torsten O., Blomqvist, Carl, Heikkilä, Päivi, Heikkinen, Tuomas, Nevanlinna, Heli, Akslen, Lars A., Bégin, Louis R., Foulkes, William D., Couch, Fergus J., Wang, Xianshu, Cafourek, Vicky, Olson, Janet E., Baglietto, Laura, Giles, Graham G., Severi, Gianluca, McLean, Catriona A., Southey, Melissa C., Rakha, Emad, Green, Andrew R., Ellis, Ian O., Sherman, Mark E., Lissowska, Jolanta, Anderson, William F., Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Provenzano, Elena, Dawson, Sarah-Jane, Dunning, Alison M., Humphreys, Manjeet, Easton, Douglas F., García-Closas, Montserrat, Caldas, Carlos, Pharoah, Paul D., Huntsman, David
Publicado em 2010

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

Por Fagerholm, Rainer, Schmidt, Marjanka K., Khan, Sofia, Rafiq, Sajjad, Tapper, William, Aittomäki, Kristiina, Greco, Dario, Heikkinen, Tuomas, Muranen, Taru A., Fasching, Peter A., Janni, Wolfgang, Weinshilboum, Richard, Loehberg, Christian R., Hopper, John L., Southey, Melissa C., Keeman, Renske, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Chenevix-Trench, Georgia, Investigators, kConFab, Lambrechts, Diether, Wildiers, Hans, Chang-Claude, Jenny, Seibold, Petra, Couch, Fergus J., Olson, Janet E., Andrulis, Irene L., Knight, Julia A., García-Closas, Montserrat, Figueroa, Jonine, Hooning, Maartje J., Jager, Agnes, Shah, Mitul, Perkins, Barbara J., Luben, Robert, Hamann, Ute, Kabisch, Maria, Czene, Kamila, Hall, Per, Easton, Douglas F., Pharoah, Paul D.P., Liu, Jianjun, Eccles, Diana, Blomqvist, Carl, Nevanlinna, Heli
Publicado no Oncotarget (2015)

Genome-wide Association Study for Ovarian Cancer Susceptibility using Pooled DNA

Por Lu, Yi, Chen, Xiaoqing, Beesley, Jonathan, Johnatty, Sharon E., deFazio, Anna, Lambrechts, Sandrina, Lambrechts, Diether, Despierre, Evelyn, Vergotes, Ignace, Chang-Claude, Jenny, Hein, Rebecca, Nickels, Stefan, Wang-Gohrke, Shan, Dörk, Thilo, Dürst, Matthias, Antonenkova, Natalia, Bogdanova, Natalia, Goodman, Marc T., Lurie, Galina, Wilkens, Lynne R., Carney, Michael E., Butzow, Ralf, Nevanlinna, Heli, Heikkinen, Tuomas, Leminen, Arto, Kiemeney, Lambertus A., Massuger, Leon F.A.G., van Altena, Anne M., Aben, Katja K., Kjaer, Susanne Krüger, Høgdall, Estrid, Jensen, Allan, Brooks-Wilson, Angela, Le, Nhu, Cook, Linda, Earp, Madalene, Kelemen, Linda, Easton, Douglas, Pharoah, Paul, Song, Honglin, Tyrer, Jonathan, Ramus, Susan, Menon, Usha, Gentry-Maharaj, Alexandra, Gayther, Simon A., Bandera, Elisa V., Olson, Sara H., Orlow, Irene, Rodriguez-Rodriguez, Lorna, Macgregor, Stuart, Chenevix-Trench, Georgia
Publicado em 2012

Association Between a Germline OCA2 Polymorphism at Chromosome 15q13.1 and Estrogen Receptor–Negative Breast Cancer Survival

Por Azzato, Elizabeth M., Tyrer, Jonathan, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Schulz-Wendtland, Rüdiger, Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Milne, Roger L., Arias, José Ignacio, Menéndez, Primitiva, Benítez, Javier, Chang-Claude, Jenny, Hein, Rebecca, Wang-Gohrke, Shan, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Beesley, Jonathan, Chen, Xiaoqing, Chenevix-Trench, Georgia, Couch, Fergus J., Olson, Janet E., Fredericksen, Zachary S., Wang, Xianshu, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, Southey, Melissa C., Devilee, Peter, Tollenaar, Rob A. E. M., Seynaeve, Caroline, García-Closas, Montserrat, Lissowska, Jolanta, Sherman, Mark E., Bolton, Kelly L., Hall, Per, Czene, Kamila, Cox, Angela, Brock, Ian W., Elliott, Graeme C., Reed, Malcolm W. R., Greenberg, David, Anton-Culver, Hoda, Ziogas, Argyrios, Humphreys, Manjeet, Easton, Douglas F., Caporaso, Neil E., Pharoah, Paul D. P.
Publicado em 2010

No evidence that GATA3 rs570613 SNP modifies breast cancer risk

Por Johnatty, Sharon E., Couch, Fergus J., Fredericksen, Zachary, Tarrell, Robert, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Gschwantler-Kaulich, Daphne, Singer, Christian F., Fuerhauser, Christine, Fink-Retter, Anneliese, Domchek, Susan M., Nathanson, Katherine L., Pankratz, Vernon S., Lindor, Noralane M., Godwin, Andrew K., Caligo, Maria A., Hopper, John, Southey, Melissa C., Giles, Graham G., Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Heikkinen, Tuomas, Aaltonen, Kirsimari, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli, Hall, Per, Czene, Kamila, Liu, Jianjun, Peock, Susan, Cook, Margaret, Platte, Radka, Evans, D. Gareth, Lalloo, Fiona, Eeles, Rosalind, Pichert, Gabriella, Eccles, Diana, Davidson, Rosemarie, Cole, Trevor, Cook, Jackie, Douglas, Fiona, Chu, Carol, Hodgson, Shirley, Paterson, Joan, Hogervorst, Frans B.L., Rookus, Matti A., Seynaeve, Caroline, Wijnen, Juul, Vreeswijk, Maaike, Ligtenberg, Marjolijn, Luijt, Rob B. van der, van Os, Theo A.M., Gille, Hans J.P., Blok, Marinus J., Issacs, Claudine, Humphreys, Manjeet K., McGuffog, Lesley, Healey, Sue, Sinilnikova, Olga, Antoniou, Antonis C., Easton, Douglas F., Chenevix-Trench, Georgia
Publicado em 2008

Association of ESR1 gene tagging SNPs with breast cancer risk

Por Dunning, Alison M., Healey, Catherine S., Baynes, Caroline, Maia, Ana-Teresa, Scollen, Serena, Vega, Ana, Rodríguez, Raquel, Barbosa-Morais, Nuno L., Ponder, Bruce A.J., Low, Yen-Ling, Bingham, Sheila, Haiman, Christopher A., Le Marchand, Loic, Broeks, Annegien, Schmidt, Marjanka K., Hopper, John, Southey, Melissa, Beckmann, Matthias W., Fasching, Peter A., Peto, Julian, Johnson, Nichola, Bojesen, Stig E., Nordestgaard, Børge, Milne, Roger L., Benitez, Javier, Hamann, Ute, Ko, Yon, Schmutzler, Rita K., Burwinkel, Barbara, Schürmann, Peter, Dörk, Thilo, Heikkinen, Tuomas, Nevanlinna, Heli, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Chen, Xiaoqing, Spurdle, Amanda, Change-Claude, Jenny, Flesch-Janys, Dieter, Couch, Fergus J., Olson, Janet E., Severi, Gianluca, Baglietto, Laura, Børresen-Dale, Anne-Lise, Kristensen, Vessela, Hunter, David J., Hankinson, Susan E., Devilee, Peter, Vreeswijk, Maaike, Lissowska, Jolanta, Brinton, Louise, Liu, Jianjun, Hall, Per, Kang, Daehee, Yoo, Keun-Young, Shen, Chen-Yang, Yu, Jyh-Cherng, Anton-Culver, Hoda, Ziogoas, Argyrios, Sigurdson, Alice, Struewing, Jeff, Easton, Douglas F., Garcia-Closas, Montserrat, Humphreys, Manjeet K., Morrison, Jonathan, Pharoah, Paul D.P., Pooley, Karen A., Chenevix-Trench, Georgia
Publicado em 2009

Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

Por Walker, Logan C, Fredericksen, Zachary S, Wang, Xianshu, Tarrell, Robert, Pankratz, Vernon S, Lindor, Noralane M, Beesley, Jonathan, Healey, Sue, Chen, Xiaoqing, Stoppa-Lyonnet, Dominique, Tirapo, Carole, Giraud, Sophie, Mazoyer, Sylvie, Muller, Danièle, Fricker, Jean-Pierre, Delnatte, Capucine, Schmutzler, Rita K, Wappenschmidt, Barbara, Engel, Christoph, Schönbuchner, Ines, Deissler, Helmut, Meindl, Alfons, Hogervorst, Frans B, Verheus, Martijn, Hooning, Maartje J, van den Ouweland, Ans MW, Nelen, Marcel R, Ausems, Margreet GEM, Aalfs, Cora M, van Asperen, Christi J, Devilee, Peter, Gerrits, Monique M, Waisfisz, Quinten, Szabo, Csilla I, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare T, Frost, Debra, Harrington, Patricia, Evans, D Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Chu, Carol, Davidson, Rosemarie, Eccles, Diana, Ong, Kai-Ren, Cook, Jackie, Rebbeck, Tim, Nathanson, Katherine L, Domchek, Susan M, Singer, Christian F, Gschwantler-Kaulich, Daphne, Dressler, Anne-Catharina, Pfeiler, Georg, Godwin, Andrew K, Heikkinen, Tuomas, Nevanlinna, Heli, Agnarsson, Bjarni A, Caligo, Maria Adelaide, Olsson, Håkan, Kristoffersson, Ulf, Liljegren, Annelie, Arver, Brita, Karlsson, Per, Melin, Beatrice, Sinilnikova, Olga M, McGuffog, Lesley, Antoniou, Antonis C, Chenevix-Trench, Georgia, Spurdle, Amanda B, Couch, Fergus J
Publicado em 2010