MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas

BACKGROUND: Uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer (HLRCC) patients are driven by fumarate hydratase (FH) inactivation or occasionally by mediator complex subunit 12 (MED12) mutations. The aim of this study was to analyse whether MED12 mutations and FH inactivation a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Kämpjärvi, Kati, Mäkinen, Netta, Mehine, Miika, Välipakka, Salla, Uimari, Outi, Pitkänen, Esa, Heinonen, Hanna-Riikka, Heikkinen, Tuomas, Tolvanen, Jaana, Ahtikoski, Anne, Frizzell, Norma, Sarvilinna, Nanna, Sjöberg, Jari, Bützow, Ralf, Aaltonen, Lauri A, Vahteristo, Pia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Genetics and Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984459/
https://ncbi.nlm.nih.gov/pubmed/27187686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.130
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