MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas

BACKGROUND: Uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer (HLRCC) patients are driven by fumarate hydratase (FH) inactivation or occasionally by mediator complex subunit 12 (MED12) mutations. The aim of this study was to analyse whether MED12 mutations and FH inactivation a...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kämpjärvi, Kati, Mäkinen, Netta, Mehine, Miika, Välipakka, Salla, Uimari, Outi, Pitkänen, Esa, Heinonen, Hanna-Riikka, Heikkinen, Tuomas, Tolvanen, Jaana, Ahtikoski, Anne, Frizzell, Norma, Sarvilinna, Nanna, Sjöberg, Jari, Bützow, Ralf, Aaltonen, Lauri A, Vahteristo, Pia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984459/
https://ncbi.nlm.nih.gov/pubmed/27187686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.130
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