Загрузка...

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

The PI3K/mTOR-pathway is the most commonly dysregulated pathway in epithelial cancers and represents an important target for cancer therapeutics. Here we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells ar...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Muranen, Taru, Selfors, Laura M., Worster, Devin T., Iwanicki, Marcin P., Song, Loling, Morales, Fabiana C., Gao, Sizhen, Mills, Gordon B., Brugge, Joan S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297962/
https://ncbi.nlm.nih.gov/pubmed/22340595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.024
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!