Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

The PI3K/mTOR-pathway is the most commonly dysregulated pathway in epithelial cancers and represents an important target for cancer therapeutics. Here we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells ar...

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Bibliographic Details
Main Authors: Muranen, Taru, Selfors, Laura M., Worster, Devin T., Iwanicki, Marcin P., Song, Loling, Morales, Fabiana C., Gao, Sizhen, Mills, Gordon B., Brugge, Joan S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297962/
https://ncbi.nlm.nih.gov/pubmed/22340595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.024
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