ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP

Aberrant activation of the PI3K/mTOR-pathway is a common feature of many cancers and an attractive target for therapy, but resistance inevitably evolves is as the case for any cancer cell targeted therapy. In animal tumor models, chronic inhibition of PI3K/mTOR initially inhibits tumor growth, but o...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Thoreen, Carson C., Kang, Seong A., Sabatini, David M., Mills, Gordon B., Brugge, Joan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161652/
https://ncbi.nlm.nih.gov/pubmed/27913436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0155
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