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Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence

Oncogene-induced senescence (OIS) is a tumor-suppressing response that must be disrupted for cancer to develop. Mechanistic insights into OIS have begun to emerge. Activation of the p53/p21(WAF1) and/or p16(INK4A) tumor-suppressor pathways is essential for OIS. Moreover, the DNA damage response, chr...

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Bibliografske podrobnosti
izdano v:Trends Biochem Sci
Main Authors: Xu, Yingxi, Li, Na, Xiang, Rong, Sun, Peiqing
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358807/
https://ncbi.nlm.nih.gov/pubmed/24818748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2014.04.004
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