Soluble E-cadherin: A critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling

E-cadherin, a cell-cell adhesion glycoprotein, is frequently down-regulated with tumorigenic progression. The extracellular domain of E-cadherin is cleaved by proteases to generate a soluble ectodomain fragment, termed sEcad, which is elevated in the urine or serum of cancer patients. In this study,...

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Détails bibliographiques
Auteurs principaux: Brouxhon, Sabine M., Kyrkanides, Stephanos, Teng, Xiaofei, Athar, Mohammad, Ghazizadeh, Soosan, Simon, Marcia, O’Banion, M. Kerry, Ma, Li
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795921/
https://ncbi.nlm.nih.gov/pubmed/23318419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.563
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