Starved epithelial cells uptake extracellular matrix for survival

Extracellular matrix adhesion is required for normal epithelial cell survival, nutrient uptake and metabolism. This requirement can be overcome by oncogene activation. Interestingly, inhibition of PI3K/mTOR leads to apoptosis of matrix-detached, but not matrix-attached cancer cells, suggesting that...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Muranen, Taru, Iwanicki, Marcin P., Curry, Natasha L., Hwang, Julie, DuBois, Cory D., Coloff, Jonathan L., Hitchcock, Daniel S., Clish, Clary B., Brugge, Joan S., Kalaany, Nada Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234072/
https://ncbi.nlm.nih.gov/pubmed/28071763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13989
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