Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Most tumors display increased glucose metabolism compared to that of normal tissues. The preferential conversion of glucose to lactate in cancer cells (the Warburg Effect) has been emphasized(1); however, the extent to which metabolic fluxes originating from glucose are utilized for alternative proc...

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Main Authors: Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine R., Bass, Adam J., Heffron, Gregory, Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew, Richardson, Andrea L, Chin, Lynda, Wagner, Gerhard, Asara, John M, Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677549/
https://ncbi.nlm.nih.gov/pubmed/21804546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.890
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