Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in tumorigenesis is striking. The gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step of serin...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mullarky, Edouard, Lucki, Natasha C., Beheshti Zavareh, Reza, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763784/
https://ncbi.nlm.nih.gov/pubmed/26831078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521548113
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