Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in tumorigenesis is striking. The gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step of serin...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mullarky, Edouard, Lucki, Natasha C., Beheshti Zavareh, Reza, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763784/
https://ncbi.nlm.nih.gov/pubmed/26831078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521548113
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