Inhibition of 3-Phosphoglycerate Dehydrogenase (PHGDH) by Indole Amides Abrogates de novo Serine Synthesis in Cancer Cells

Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there has been considerable interest in developing pharmacological agents to target this pathway. He...

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發表在:Bioorg Med Chem Lett
Main Authors: Mullarky, Edouard, Xu, Jiayi, Robin, Anita D., Huggins, David J., Jennings, Andy, Noguchi, Naoyoshi, Olland, Andrea, Lakshminarasimhan, Damodharan, Miller, Michael, Tomita, Daisuke, Michino, Mayako, Su, Taojunfeng, Zhang, Guoan, Stamford, Andrew W., Meinke, Peter T., Kargman, Stacia, Cantley, Lewis C.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702104/
https://ncbi.nlm.nih.gov/pubmed/31327531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.07.011
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