Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)

For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the serine synthetic pathway, and particularly of the phosp...

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Détails bibliographiques
Publié dans:Pharmaceuticals (Basel)
Auteurs principaux: Spillier, Quentin, Ravez, Séverine, Unterlass, Judith, Corbet, Cyril, Degavre, Charline, Feron, Olivier, Frédérick, Raphaël
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7168936/
https://ncbi.nlm.nih.gov/pubmed/31979167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13020020
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