Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

Due to rising costs and the difficulty to identify new targets, drug repurposing appears as a viable strategy for the development of new anti-cancer treatments. Although the interest of disulfiram (DSF), an anti-alcohol drug, to treat cancer was reported for many years, it is only very recently that...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Spillier, Quentin, Vertommen, Didier, Ravez, Séverine, Marteau, Romain, Thémans, Quentin, Corbet, Cyril, Feron, Olivier, Wouters, Johan, Frédérick, Raphaël
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426982/
https://ncbi.nlm.nih.gov/pubmed/30894617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41187-0
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