Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and dopamine β-hydroxylase

BACKGROUND: Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catecholamine metabolism, dopamine β-hydroxylase (DβH), which converts dopamine to norepinephrine. A vari...

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Autors principals: Kosten, Thomas R., Wu, Grace, Huang, Wen, Harding, Mark J., Hamon, Sara C., Lappalainen, Jaakko, Nielsen, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514624/
https://ncbi.nlm.nih.gov/pubmed/22906516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.07.011
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