Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and α(1A)-adrenoceptor gene variation

Disulfiram is a cocaine addiction pharmacotherapy that inhibits dopamine β-hydroxylase (DβH) and reduces norepinephrine production. We examined whether a functional variant of the ADRA1A gene (Cys to Arg at codon 347 in exon 2, Cys347Arg) may enhance treatment response through decreased stimulation...

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Main Authors: Shorter, D., Nielsen, D.A., Huang, W., Harding, M. J., Hamon, S.C., Kosten, T.R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818518/
https://ncbi.nlm.nih.gov/pubmed/23849431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2013.05.014
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