α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH)

Given the putative role of PHGDH in cancer, development of inhibitors is required to explore its function. In this context, we established and validated a straightforward enzymatic assay suitable for high-throughput screening and we identified inhibitors with similar chemical scaffolds. Through a co...

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Pubblicato in:J Med Chem
Autori principali: Ravez, Séverine, Corbet, Cyril, Spillier, Quentin, Dutu, Alice, Robin, Anita D., Mullarky, Edouard, Cantley, Lewis C., Feron, Olivier, Frédérick, Raphaël
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603230/
https://ncbi.nlm.nih.gov/pubmed/28085281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01166
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