Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs, pancreatic cancers preferentially utilize a metabolic pathway through the enzyme aspartate aminotransferase 1 [also known as glutamate oxaloace...

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Publicado no:Biochemistry
Main Authors: Holt, Melissa C., Assar, Zahra, Zavareh, Reza Beheshti, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M., Cantley, Lewis C., Kimmelman, Alec C., Stein, Adam J., Lairson, Luke L., Lyssiotis, Costas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487875/
https://ncbi.nlm.nih.gov/pubmed/30365304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00914
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