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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
Loss of extracellular matrix (ECM) attachment leads to metabolic impairments that limit cellular energy production. Characterization of the metabolic alterations induced by ECM detachment revealed a dramatic decrease in uptake of glucose, glutamine, and pyruvate, and a consequent decrease in flux th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165936/ https://ncbi.nlm.nih.gov/pubmed/21852536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16771811 |
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