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Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals
The EGF-stimulated ERK/MAPK pathway is a key conduit for cellular proliferation signals and a therapeutic target in many cancers. Here, we characterize two central quantitative aspects of this pathway: the mechanism by which signal strength is encoded and the response curve relating signal output to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151532/ https://ncbi.nlm.nih.gov/pubmed/23219535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.11.002 |
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