Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Most tumors display increased glucose metabolism compared to that of normal tissues. The preferential conversion of glucose to lactate in cancer cells (the Warburg Effect) has been emphasized(1); however, the extent to which metabolic fluxes originating from glucose are utilized for alternative proc...

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Detaylı Bibliyografya
Asıl Yazarlar: Locasale, Jason W., Grassian, Alexandra R., Melman, Tamar, Lyssiotis, Costas A., Mattaini, Katherine R., Bass, Adam J., Heffron, Gregory, Metallo, Christian M., Muranen, Taru, Sharfi, Hadar, Sasaki, Atsuo T., Anastasiou, Dimitrios, Mullarky, Edouard, Vokes, Natalie I., Sasaki, Mika, Beroukhim, Rameen, Stephanopoulos, Gregory, Ligon, Azra H., Meyerson, Matthew, Richardson, Andrea L, Chin, Lynda, Wagner, Gerhard, Asara, John M, Brugge, Joan S., Cantley, Lewis C., Vander Heiden, Matthew G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677549/
https://ncbi.nlm.nih.gov/pubmed/21804546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.890
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