Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications

INTRODUCTION: Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation car...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Muranen, Taru A, Greco, Dario, Fagerholm, Rainer, Kilpivaara, Outi, Kämpjärvi, Kati, Aittomäki, Kristiina, Blomqvist, Carl, Heikkilä, Päivi, Borg, Åke, Nevanlinna, Heli
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262202/
https://ncbi.nlm.nih.gov/pubmed/21542898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados