Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications

INTRODUCTION: Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. We investigated gene copy-number aberrations and gene-expression profiles that are typical for breast tumors of CHEK2 1100delC-mutation car...

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Detaylı Bibliyografya
Asıl Yazarlar: Muranen, Taru A, Greco, Dario, Fagerholm, Rainer, Kilpivaara, Outi, Kämpjärvi, Kati, Aittomäki, Kristiina, Blomqvist, Carl, Heikkilä, Päivi, Borg, Åke, Nevanlinna, Heli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262202/
https://ncbi.nlm.nih.gov/pubmed/21542898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3015
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