mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer

Activating mutations of the PIK3CA gene occur frequently in breast cancer, and inhibitors that are specific for phosphatidylinositol 3-kinase (PI3K) p110α, such as BYL719, are being investigated in clinical trials. In a search for correlates of sensitivity to p110α inhibition among PIK3CA-mutant bre...

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Detalhes bibliográficos
Main Authors: Elkabets, Moshe, Vora, Sadhna, Juric, Dejan, Morse, Natasha, Mino-Kenudson, Mari, Muranen, Taru, Tao, Jessica, Campos, Ana Bosch, Rodon, Jordi, Ibrahim, Yasir H., Serra, Violeta, Rodrik-Outmezguine, Vanessa, Hazra, Saswati, Singh, Sharat, Kim, Phillip, Quadt, Cornelia, Liu, Manway, Huang, Alan, Rosen, Neal, Engelman, Jeffrey A., Scaltriti, Maurizio, Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935768/
https://ncbi.nlm.nih.gov/pubmed/23903756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005747
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