Genetic modifiers of CHEK2*1100delC associated breast cancer risk

PURPOSE: CHEK2*1100delC is a founder variant in European populations conferring a 2–3 fold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have inve...

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出版年:Genet Med
主要な著者: Muranen, Taru A., Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul D.P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Bojesen, Stig E., Nordestgaard, Børge G., Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V., Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Peto, Julian, dos Santos Silva, Isabel, Couch, Fergus J., Olson, Janet E., Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Cross, Simon S., Sawyer, Elinor J., Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John W.M., Fasching, Peter A., Beckmann, Matthias W., Andrulis, Irene L., Knight, Julia A., Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G., Milne, Roger L., Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L., Southey, Melissa C., John, Esther M., Whittemore, Alice S., Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F., Schmidt, Marjanka K., Nevanlinna, Heli
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382131/
https://ncbi.nlm.nih.gov/pubmed/27711073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2016.147
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