Genetic modifiers of CHEK2*1100delC associated breast cancer risk

PURPOSE: CHEK2*1100delC is a founder variant in European populations conferring a 2–3 fold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with CHEK2*1100delC is modified by other genetic factors in a multiplicative fashion. We have inve...

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Publicado no:Genet Med
Main Authors: Muranen, Taru A., Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul D.P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Bojesen, Stig E., Nordestgaard, Børge G., Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V., Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Peto, Julian, dos Santos Silva, Isabel, Couch, Fergus J., Olson, Janet E., Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Cross, Simon S., Sawyer, Elinor J., Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John W.M., Fasching, Peter A., Beckmann, Matthias W., Andrulis, Irene L., Knight, Julia A., Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G., Milne, Roger L., Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L., Southey, Melissa C., John, Esther M., Whittemore, Alice S., Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F., Schmidt, Marjanka K., Nevanlinna, Heli
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382131/
https://ncbi.nlm.nih.gov/pubmed/27711073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2016.147
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