Sensitivity to systemic therapy for metastatic breast cancer in CHEK2 1100delC mutation carriers

PURPOSE: The role of CHEK2 in DNA repair by homologous recombination suggests that CHEK2-associated breast cancer (BC) patients might be more sensitive to chemotherapy inducing double-strand DNA breaks, but results hereon are lacking. We compared the sensitivity to first-line chemotherapy and endocr...

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Pubblicato in:J Cancer Res Clin Oncol
Autori principali: Kriege, Mieke, Jager, Agnes, Hollestelle, Antoinette, Berns, Els M. J. J., Blom, Jannet, Meijer-van Gelder, Marion E., Sieuwerts, Anieta M., van den Ouweland, Ans, Collée, J. Margriet, Kroep, Judith R., Martens, John W. M., Hooning, Maartje J., Seynaeve, Caroline
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
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Original Article – Clinical Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543421/
https://ncbi.nlm.nih.gov/pubmed/25958056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-015-1981-7
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