The CHEK2 1100delC Mutation Identifies Families with a Hereditary Breast and Colorectal Cancer Phenotype

Because of genetic heterogeneity, the identification of breast cancer–susceptibility genes has proven to be exceedingly difficult. Here, we define a new subset of families with breast cancer characterized by the presence of colorectal cancer cases. The 1100delC variant of the cell cycle checkpoint k...

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Autori principali: Meijers-Heijboer, Hanne, Wijnen, Juul, Vasen, Hans, Wasielewski, Marijke, Wagner, Anja, Hollestelle, Antoinette, Elstrodt, Fons, van den Bos, Renate, de Snoo, Anja, Tjon A Fat, Grace, Brekelmans, Cecile, Jagmohan, Shantie, Franken, Patrick, Verkuijlen, Paul, van den Ouweland, Ans, Chapman, Pamela, Tops, Carli, Möslein, Gabriela, Burn, John, Lynch, Henry, Klijn, Jan, Fodde, Riccardo, Schutte, Mieke
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Human Genetics 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180284/
https://ncbi.nlm.nih.gov/pubmed/12690581
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